Fit and very good waiting. Adult want real sex Callahan come to OKC often.
Are you ready to fulfill your fantasies and desires. Your very sexy. I want to eat some pussy tonight I am a tall black man that would like to eat some sweet white pussy tonight. Pin me down, tie me up, me up and leave me a creamy surprise somewhere. (Texts only) Please put name in text.
Methylphenidate , sold under various trade names, Ritalin being one of the most commonly known, is a central nervous system CNS stimulant of the phenethylamine  and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder ADHD and narcolepsy. Medical use began in ; the drug has become increasingly prescribed since the s, when the diagnosis of ADHD became more widely accepted.
ADHD and other similar conditions are believed to be linked to sub-par performance of the dopamine and norepinephrine functions in the brain, primarily in the prefrontal cortex , responsible for executive function e.
Methylphenidate acts by blocking the dopamine transporter and norepinephrine transporter , leading to increased concentrations of dopamine and norepinephrine within the synaptic cleft. This effect in turn leads to increased neurotransmission of dopamine and norepinephrine.
Methylphenidate is a commonly prescribed psychostimulant and works by increasing the activity of the central nervous system. Meta-analyses and systematic reviews of magnetic resonance imaging MRI studies suggest that long-term treatment with ADHD stimulants specifically, amphetamine and methylphenidate decreases abnormalities in brain structure and function found in subjects with ADHD.
Current models of ADHD suggest that it is associated with functional impairments in some of the brain's neurotransmitter systems , [note 1] particularly those involving dopamine and norepinephrine. Methylphenidate may provide possible protection from methamphetamine induced dopamine neuron damage and possible protection from Parkinson disease according to 1 review. Narcolepsy , a chronic sleep disorder characterized by overwhelming daytime drowsiness and sudden need for sleep, is treated primarily with stimulants.
Methylphenidate is considered effective in increasing wakefulness, vigilance, and performance. Methylphenidate may be used in addition to an antidepressant for refractory major depressive disorder. It can also improve depression in several groups including stroke , cancer , and HIV-positive patients.
Excessive doses of methylphenidate, above the therapeutic range, can interfere with working memory and cognitive control. Methylphenidate is contraindicated for individuals using monoamine oxidase inhibitors e. The US FDA gives methylphenidate a pregnancy category of C, and women are advised to only use the drug if the benefits outweigh the potential risks. In , empirical literature included 63 cases of prenatal exposure to methylphenidate across three empirical studies.
Methylphenidate is generally well tolerated. Gastrointestinal adverse effects may include abdominal pain and weight loss. Cardiac adverse effects may include palpitations , changes in blood pressure and heart rate typically mild , tachycardia rapid resting heart rate , and Raynaud's phenomenon reduced blood flow to the hands and feet. Hyperhidrosis increased sweating is common. Chest pain is rarely observed.
There is some evidence of mild reductions in growth rate with prolonged treatment in children, but no causal relationship has been established and reductions do not appear to persist long-term.
The Daytrana patch has a much higher rate of dermal reactions than oral methylphenidate. Methylphenidate can worsen psychosis in psychotic patients, and in very rare cases it has been associated with the emergence of new psychotic symptoms. Libido disorders, disorientation , and hallucinations are very rarely reported. Priapism is a very rare adverse event that can be potentially serious. USFDA-commissioned studies from indicate that in children, young adults, and adults there is no association between serious adverse cardiovascular events sudden death , heart attack , and stroke and the medical use of methylphenidate or other ADHD stimulants.
Because some adverse effects may only emerge during chronic use of methylphenidate, a constant watch for adverse effects is recommended. The symptoms of a moderate acute overdose on methylphenidate primarily arise from central nervous system overstimulation; these symptoms include: Pharmacological texts describe methylphenidate as a stimulant with effects, addiction liability, and dependence liability similar to amphetamine , a compound with moderate liability among addictive drugs ;   accordingly, addiction and psychological dependence are possible and likely when methylphenidate is used at high doses as a recreational drug.
Methylphenidate has shown some benefits as a replacement therapy for individuals who are addicted to and dependent upon methamphetamine. Its effectiveness in treatment of cocaine or psychostimulant addiction or psychological dependence has not been proven and further research is needed.
Methylphenidate has the potential to induce euphoria due to its pharmacodynamic effect i. Methylphenidate may inhibit the metabolism of coumarin anticoagulants , certain anticonvulsants , and some antidepressants tricyclic antidepressants and selective serotonin reuptake inhibitors. Concomitant administration may require dose adjustments, possibly assisted by monitoring of plasma drug concentrations.
When methylphenidate is coingested with ethanol , a metabolite called ethylphenidate is formed via hepatic transesterification ,   not unlike the hepatic formation of cocaethylene from cocaine and alcohol. The reduced potency of ethylphenidate and its minor formation means it does not contribute to the pharmacological profile at therapeutic doses and even in overdose cases ethylphenidate concentrations remain negligible.
Methylphenidate primarily acts as a norepinephrine—dopamine reuptake inhibitor NDRI. It is a benzylpiperidine and phenethylamine derivative which also shares part of its basic structure with catecholamines.
Methylphenidate is most active at modulating levels of dopamine DA and to a lesser extent norepinephrine. Both amphetamine and methylphenidate are predominantly dopaminergic drugs, yet their mechanisms of action are distinct. Methylphenidate acts as a norepinephrine—dopamine reuptake inhibitor while amphetamine is both a releasing agent and reuptake inhibitor of dopamine and norepinephrine. Methylphenidate's mechanism of action in the release of dopamine and norepinephrine is fundamentally different from most other phenethylamine derivatives , as methylphenidate is thought to increase neuronal firing rate ,     whereas amphetamine reduces firing rate, but causes monoamine release by reversing the flow of the monoamines through monoamine transporters via a diverse set of mechanisms, including TAAR1 activation and modulation of VMAT2 function, among other mechanisms.
Methylphenidate has both dopamine transporter and norepinephrine transporter binding affinity, with the dextromethylphenidate enantiomers displaying a prominent affinity for the norepinephrine transporter.
Both the dextrorotary and levorotary enantiomers displayed receptor affinity for the serotonergic 5HT 1A and 5HT 2B subtypes, though direct binding to the serotonin transporter was not observed. Methylphenidate may protect neurons from the neurotoxic effects of Parkinson's disease and methamphetamine abuse. The dextrorotary enantiomers are significantly more potent than the levorotary enantiomers, and some medications therefore only contain dexmethylphenidate. Methylphenidate has been identified as a sigma-1 receptor agonist in rats.
Dextromethylphenidate is much more bioavailable than levomethylphenidate when administered orally, and is primarily responsible for the psychoactivity of racemic methylphenidate. Contrary to the expectation, taking methylphenidate with a meal speeds absorption. Methylphenidate is metabolized into ritalinic acid by CES1A1. Dextromethylphenidate is selectively metabolized at a slower rate than levomethylphenidate.
Four isomers of methylphenidate are possible, since the molecule has two chiral centers. One pair of threo isomers and one pair of erythro are distinguished, from which primarily d-threo-methylphenidate exhibits the pharmacologically desired effects. When the drug was first introduced it was sold as a 4: Since the threo isomers are energetically favored, it is easy to epimerize out any of the undesired erythro isomers.
The drug that contains only dextrorotatory methylphenidate is sometimes called d-TMP, although this name is only rarely used and it is much more commonly referred to as dexmethylphenidate , d-MPH, or d-threo-methylphenidate. The concentration of methylphenidate or ritalinic acid , its major metabolite, may be quantified in plasma, serum or whole blood in order to monitor compliance in those receiving the drug therapeutically, to confirm the diagnosis in potential poisoning victims or to assist in the forensic investigation in a case of fatal overdosage.
Generic forms are produced by numerous pharmaceutical companies throughout the world. Currently available forms include a variety of tablets and capsules, an adhesive-based matrix transdermal system transdermal patch , and an oral suspension liquid syrup.
The dextrorotary enantiomer of methylphenidate, known as dexmethylphenidate , is sold as a generic and under the brand names Focalin and Attenade in both an immediate-release and an extended-release form. In some circumstances it may be prescribed instead of methylphenidate, however it has no significant advantages over methylphenidate at equipotent dosages and so it is sometimes considered to be an example of an evergreened drug.
Methylphenidate was originally available as an immediate-release racemic mixture formulation under the Novartis trademark name Ritalin, although a variety of generics are now available, some under other brand names. Extended-release methylphenidate products include:. Concerta tablets are marked with the letters "ALZA" and followed by: Novartis and followed by: In total, each capsule is effective for about eight hours.
Quillivant XR is an extended-release oral suspension after reconstitution with water: It was designed and is patented and made by Pfizer. The medication comes in various sizes from 60ml to ml after reconstitution. The bottle must be shaken vigorously for ten seconds prior to administration via included oral syringe to ensure proper ratio.
Generic immediate-release methylphenidate is relatively inexpensive. Methylphenidate was first synthesized in ,  and was identified as a stimulant in Methylphenidate was synthesized by Ciba now Novartis chemist Leandro Panizzon. He named the drug after his wife, nicknamed Rita, who used Ritalin to compensate for low blood pressure.
Subsequent studies of the racemates showed that the central stimulant activity is associated with the threo racemate and were focused on the separation and interconversion of the erythro isomer into the more active threo isomer. Methylphenidate was first used to allay barbiturate -induced coma, narcolepsy and depression. Methylphenidate has been the subject of controversy in relation to its use in the treatment of ADHD.
The prescription of psychostimulant medication to children to reduce ADHD symptoms has been a major point of criticism. One of the highest use of methylphenidate medication is in Iceland, [ citation needed ] where research shows that the drug was the most commonly abused substance among intravenous substance abusers.
Treatment of ADHD by way of methylphenidate has led to legal actions, including malpractice suits regarding informed consent , inadequate information on side effects , misdiagnosis , and coercive use of medications by school systems. In the US and the UK, it is approved for use in children and adolescents. Methylphenidate may have benefit as a treatment of apathy in patients with Alzheimer's disease.
From Wikipedia, the free encyclopedia. Not to be confused with Ethylphenidate. C Risk not ruled out. List of methylphenidate analogues. Methylphenidate preparation elucidated by Axten et al. Classic methylphenidate synthesis . Another synthesis route of methylphenidate which applies Darzens reaction to obtain aldehyde as an intermediate.
This route is significant for its selectivity. National Center for Biotechnology Information. Retrieved 8 October Catecholamine Influences on Prefrontal Cortical Functions". Neuroscientific Basis and Practical Applications 4th ed. Journal of Clinical Psychopharmacology. Can J Clin Pharmacol. Archived from the original PDF on/p>
Not into BBW, please be ddf as I am. Ages 34 to 45 please. Wives looking hot sex Pussy is hungry. Sexy lady looking porno orgy Glendale "by each and every kindness we birth our future" Join me in creating a for the next part of our lives.
Creative ,kind, intelligent, handsome, seeking a LTR and between the age of 45 and 60 gets a response. Tell me about yourself- your past, your present and your future. Please be in a position of stable income and management level employment, and desire a monogamous, give and take relationship with realistic expectations.
Love, honor and respect, are required. We won't get to point B without chemistry. For me that requires you have a keen intellect without arrogance, be on the tall side but not too thin, have a great smile with good , be reasonably fit and omit the LOLs, smiley faces and sexual innuendo in your communication with me.
Z Sexy lady looking fucking Lake Forest. Sex and Swingers Personals Contact Us. Ride my 9" cock while he rides his bike. Why do I say Zombies? Because if you walk by the millionaire's and billionaire's yachts in a harbor during the evening, what you see is the flickering blue-lights of televisions screens. How do they spend their precious free time? Zombies try to get their name on as many pieces of paper as possible which say that they own property so they can collect rent and watch more television.
If you pay rent to anyone you are a Zombie-maker. Don't be a Zombie-maker. Money disconnects people from a brilliant life of delivering their value and focuses them a survival life of trying to make money. An activated edgeworker serves as a bridge to archearchy, weaving the global network of one-hundred million interdepending regenerative-culture nanonations. You do this by becoming a Trainer-Trainer Trainer. When there are Trainer-Trainer Trainers humanity will rapidly upgrade its thoughtware, because each Trainer-Trainer Trainer will train Trainer-Trainers, and each Trainer-Trainer will train Trainers, and each Trainer will train clients, customers, and participants.
This is how we generate one billion newly-initiated radically-responsible adults in the world. I welcome collaborators helping to make these things happen A torus of transformational facilitators using Possibility Management.
Along the way we intend to ignite Trainer-Trainer Trainers. Every village needs its midwives, sorceresses, memetic wizards, alchemists, element shifters, magicians, and next-culture shamans Life-enhancing books from some of your favorite authors: Radiant Joy Brilliant Love. Directing The Power of Conscious Feelings. Next culture personal development We learn to empower each other in our full potential, living life at our best, free of conditioning and limitations.
We want to see the human race thriving on Earth, co-creating the world we each want to live in! The concept that land on Earth can be owned by either a person or an organization is a superstition, easy to understand, but without basis in reality.
The laws that declare the legality of buying and selling land are based on an ecocidal paradigm. There is already a precedent that nation-states exist wherever the bearer of a passport of that nation-state stands. Therefore nation-states do not have to be associated with plots of land on Earth. A nanonation is a cultural-context-space held by a group of three or more people mutually committed to each other while serving a common purpose.
How to build and occupy your own nanonation: Following an impulse from Marion Callahan in , a team of between 3 and 9 Possibility Managers followed the whims of Gaia through South-East Asia and around the world for three-quarters of a year.
During the journey we made video interviews with over 60 astonishing edgeworkers about their projects and the insights that allowed them to succeed. Who wants to do this with me? Mike coasts to a stop on his ten-speed bike and leans its frame against the stone wall of the village bakery. He pushes open the glass door, walks in and approaches the counter. A half-bald middle-aged man wearing a well-worn baker's apron studies his actions.
The baker wraps the fresh warm loaf in brown paper and places it on top of the glass display case. Mike hands the baker a five Euro bill. He squints directly into Mike's eyes and speaks. You think that piece of paper has value. If I don't value that paper how can there be a fair exchange? There is no exchange-rate between that paper and the currency I use. I bake bread because it turns me on to make bread for people in our community. If I exchanged my bread for that money then I would contaminate our local culture with an artifact from a culture that is rapidly headed for self-destruction.
My culture is too precious to contaminate it with that money. This is the story of a slight intervention by Gaia, the living spirit of planet earth. Due to the actions of mankind Gaia has gradually come to fear for her life.
After great deliberation she has decided to take action. She reaches through the field of coincidences to influence the lives of a few extraordinary human beings. Her wish is to continue playing the infinite game of evolution. This is the same wish as mankind - although many have forgotten. Gaia is a gentle and kind Goddess playing against unimaginable forces of darkness. There is not much hope that she will succeed. Using education instead of force she delicately unbalances the disorder and invites her allies to build the Hidden University.
Creating is different from pro-creating. The village needs my gift. Heat waves shimmer beyond the wall of the dirt-floored compound.
Cicadas screech louder and it interrupts her thinking. Her gaze drops to her arms where her baby, only a few days old, stops breathing, shudders once, and dies. The flies are already eating his face. There is nothing anyone can do to help, and no one to do it besides. She waits a few moments to establish contact with his soul and then speaks the death prayer to guide his passage. JET and Eddie develop a news-scanning program which detects the intention vectors forcing modern culture towards oblivion.
Someone is taking civilization down on purpose, while Mother nature fights to initiate humans into adulthood. If civilization is the eggshell, what is hatching out? And who is the chicken? It's time for JET and Eddie to invent a new game. Carola and Suzanne are ironing. They wear t-shirts with a big logo that says ' Ironing Maidens.
Wrinkles her nose at the stink. It is because I get to spend my time with you telling me jokes instead of with university bureaucrats telling me they are going to reduce my funding. Had a rough football game… This is what I am thinking about. What are you thinking about? I was thinking how I can only choose to use an opportunity when that opportunity is present. So having an opportunity is one wrinkle of cloth touching another wrinkle.
If you choose to use an opportunity you jump from one wrinkle to the next wrinkle. And each choice you make changes everything. Has stopped ironing and stares at Suzanne. But what is most amazing is to get it that if human beings in the future ever figure out how to do time travel - to jump from one time-wrinkle to the next - then the time travelers are already here.
In the book Journey to Ixtlan , Carlos Castaneda briefly mentions a set of distinctions he got from his teacher Don Juan Matus, who called these ideas the four enemies of a man on the path. I am sure that women on the path have the same enemies…. Many years after first learning of them their importance finally struck me.
If it is wise to know your selves, it would be equally wise to know your enemies. Your selves and your enemies are dancing together in vampire and victim gyrations. The way to get to know your enemies is to fight them. By struggling against your enemies you discover the profoundness of the grip they have on you and you discover who you are. You detect where in you they hide and by what mechanism the enemies lock into your Being and you discover your inner structure.
You were trained that fear is bad, fear is negative, fear means something is wrong and should be avoided at all costs. Not only that, it usually retracts you reflexively back into your comfort zone, the turtle popping back into his shell. Perhaps you never again explore in that direction. How many opportunity doors have you closed this way? The star looks fit in a sexy silver bikini as she poses on Miami beach We have written multiple posts about men who have lower sexual desire too.
First glimpse of Peter Jackson's stunning new WWI film in which he colourises hours of grainy archive Buy her some massage oil and have it waiting in your room warming in hot water. Fitness trackers tend to overestimate the number of steps taken by. Wife want sex tonight Callahan Online: Back to top Home News U. I never knew the core reasons why she was rejecting me, neither did she but they have come to light. Driver deliberately mows down group of screaming pedestrians who fail to get out the way fast Hampstead, NH - Willis G.
Need was eating away at his insides. you make every woman jump through hoops like this, I'm amazed you get any sex at all. We're both adults, Finn. We' re. Catina Callahan's 7 research works with citations and reads, The findings of this study indicate a critical need to develop culturally relevant HIV . and later cocaine dependence and adult sex trading among drug using women. I like to call the Callahan Theory of Temporal Displacement, or CTTD. According to If that's true, and my wife swears it is, then that narrows my visible world even further. A couple of years later, I again volunteer for an adult literacy program.